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Grants to USA Investigators for Research Related to Bone Cancer


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Fight Osteosarcoma Together Super Grant

St. Baldrick’s Foundation, Battle Osteosarcoma, Children’s Cancer Research Fund, CureSearch for Children’s Cancer, Michael and April Egge, and The Osteosarcoma Collaborative

Grant Provider's 990

Agency: Foundation

GrantWatch ID #206793

Grant Description

Grants to USA investigators for research related to bone cancer. Applicants are required to submit a letter of intent prior to a full application. Funding is intended to support research to create therapeutic options for patients as quickly as possible, aiming for a clinical trial in the next 1 to 3 years.

This Request For Applications (RFA) seeks to support high-impact osteosarcoma research with a focus on moving quickly toward improvements in outcomes for patients. Projects can be investigator-initiated, intervention-oriented studies or translational research to create new therapeutic options. Applicants are required to propose time-dependent, measurable milestones to ensure completion of study objectives and clearly state how results at each milestone will be used in measuring research outcomes. The project budget should closely reflect the milestones. The funder will be updated through written outcomes reports every year, a phone call update every six months, and a site visit or videoconference at the end of each year thereafter. Applications may be from individuals or teams, with a preference for team science.

Requirements and Considerations:

  • The focus of applications should be on creating new therapeutic options for patients as quickly as possible, aiming for a clinical trial in the next 1 to 3 years. Applications may focus on first line treatment or relapsed/metastatic disease.
  • Essentially all therapeutic modalities are accepted, with a preference for molecular informed therapies, immunotherapies and combination, multi-modal therapies.
  • The focus of the funded work will be treatment efficacy, but the inclusion of correlative studies to identify biomarkers for response will be well received.
  • Methods that allow dynamic monitoring of disease burden and/or therapeutic efficacy will also be considered. Note, however, that the discovery of novel therapeutic interventions will be given priority.
  • Both hypothesis-driven and hypothesis-neutral (e.g., drug screening and genome-wide molecular characterization) approaches will be considered, as long as the outcome of the project leads to actionable therapeutic intervention within the suggested time frame.
  • Proposals without clear path to the therapeutic interventions will receive a low priority.
  • Cross discipline collaboration is encouraged, with each investigator’s role and responsibility clearly outlined in the proposal.
  • Proposals must include proposed timeline with anticipated milestones for each quarter.
  • Proposals must include a clear plan for the sharing of data.
  • Grant subject to annual reporting to grant scientific review team. 

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  • Others (see text field entitled "Additional Eligibility Criteria" for clarification)

Additional Eligibility Criteria:

- Applications will be accepted from both individual researchers/labs and from consortia, with team science preferred.
- Institutions must be located in the United States.
- Teams with existing international collaborations are eligible to apply, however clinical trial development must be available to U.S. patients.
- Applicants need not be American citizens; however, they must work at an academic, medical, or research institution within the United States.
- An institution may submit more than one LOI/Application for this RFA.
- A researcher can only apply once as the lead Principal Investigator.
- Applicants should hold at least a M.D., D.O., Ph.D., DVM, or international equivalent degree by the date the award becomes effective
- Laboratory scientists and clinical investigators must have adequate space to conduct proposed research and protected time for research, verified by a Letter of Institutional Support.
- The applicant must not hold an active grant from any partner organizations for the scope of work proposed in this application.


St. Baldrick’s funds may not be used for human embryonic stem cell research.

This grant does not provide funds for items such as:
- Secretarial/administrative salaries.
- Student tuition
- Office and laboratory furniture.
- Office equipment and supplies.
- Recruiting and relocation expenses.
- Non-medical services to patients (travel to a clinical site or patient incentives are allowable expenses).
- Construction, renovation, or maintenance of buildings/laboratories.
- Professional association membership dues
- Scientific publication subscriptions

Pre-Application Information:

Letter of Intent (LOI), application and required documents must be submitted by the Principal Investigator, in English, online through ProposalCentral before 5 p.m. EASTERN TIME on the deadline.

Only applicants with LOIs deemed most meritorious and aligned with program’s goals will be invited to submit full applications.
- Letter of intent due: December 9, 2022 before 5pm EASTERN TIME
- Letter of intent approval by: January 20, 2023
- Full proposal due: March 3, 2023 before 5pm EASTERN TIME Notification of award by: June 1, 2023
- Project start date: July 1, 2023

Term of Contract:

The award amount will total $500,000/year, distributed annually, pro rata, over a three-year period.

Funding starting from the 2nd installment will be evaluated based on research progress. Continuation of funding will be dependent upon successful completion of each milestone and is contingent upon favorable review of the grantee’s progress reports by the Scientific Advisory Council.

Contact Information:

Submit LOI at

For grant inquiries:
St. Baldrick’s Foundation
Department of Grants Administration
(626) 792-8247, extension 236

For help using the online application system:
ProposalCentral Customer Support
(800) 875-2562

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